Mesothelioma Early Detection by VOCs
This is a two phase study, The first phase (phase 1) will identify potential biomarkers among asbestos exposed individuals with pleural mesothelioma. The second phase (phase 2), is a double blinded case-matched controlled study to determine the predictive capability, sensitivity, and specificity of these biomarkers in detecting early stage pleural mesothelioma. Biomarkers in the form of volatile organic compounds (VOC) in exhaled breath samples from subjects with either pleural mesothelioma or pleural plaques, will be evaluated. A biomarker present in serum will also be concurrently evaluated in the same cohort. The soluble serum biomarker mesothelin related peptides (SMRP), which has been posited as a biomarker for mesothelioma, will be analyzed for its relationship to the breath VOC profile.
Checked against the public recordLast updated Aug 10, 2026 · Source: ClinicalTrials.gov
What this study is about
- Purpose
- Not specified
- Study type
- Observational
- Phase
- Not applicable
- Sponsor
- Henry Ford Health System
- Interventions being studied
- Not specified
How this study is categorized
These labels come from structured fields and exact terms in the public record.
Who may be able to participate
Inclusion Criteria * Male or Female over 18 years of age * Clinical diagnosis of pleural mesothelioma or presence of pleural plaques on X-Ray * Documented exposure to asbestos * Must be able to provide breath sample * Must be able to provide relevant medical information Exclusion Criteria * Presence of malignancies other that mesothelioma within the past 6 months * Treatment for any malignancies other than mesothelioma within the past 6 months * Inability to provide past clinical information * Inability to perform breath collection procedure * Smoking or consuming alcohol within two hours of conducting breath collection procedure
Important: This is the sponsor’s public criteria, not a determination of eligibility. The study team must review your individual situation.
U.S. locations
- Consultants in Sleep and Pulmonary MedicineFarmington Hills, Michigan
Source and freshness
Processed from ClinicalTrials.gov. Last public update: Aug 10, 2026. Always confirm current availability with the study team.