Active Not RecruitingPhase 2NCT05676931

Study With Various Immunotherapy Treatments in Participants With Lung Cancer

The purpose of this study is to assess the objective response rate (ORR) of immunotherapy-based combination therapy and to assess the safety and tolerability of immunotherapy-based combination therapy.

Checked against the public recordLast updated Jun 1, 2026 · Source: ClinicalTrials.gov

StatusActive Not Recruiting
PhasePhase 2
U.S. locations53
SponsorGilead Sciences
01
Study overview

What this study is about

Purpose
Treatment
Study type
Interventional
Phase
Phase 2
Sponsor
Gilead Sciences
Interventions being studied
Drug: Domvanalimab; Drug: Quemliclustat; Drug: Zimberelimab; Drug: Docetaxel; Drug: Platinum-Based Doublet
02
Explore related studies

How this study is categorized

These labels come from structured fields and exact terms in the public record.

03
Public criteria

Who may be able to participate

Inclusion Criteria: * Histologically or cytologically documented Stage IV metastatic, NSCLC * Eastern Cooperative Oncology Group performance status (ECOG PS) of 0 to 1 * At least one measurable target lesion per RECIST v1.1. * Adequate organ function * Participants must be willing to provide adequate tumor tissue Exclusion Criteria: * Underlying medical conditions that, in the Investigator's or Sponsor's opinion, will make the administration of Investigational Product(s) (IPs) hazardous * Use of any live vaccines against infectious diseases within 28 days of first dose of IP(s). * Use of supra-physiologic doses of corticosteroids (\> 10 mg/day of oral prednisone or equivalent) or immunosuppressive medications ≤ 14 days before the initiation of study treatment (absorbable topical corticosteroids are not excluded). * Has known psychiatric or substance abuse disorders that would interfere with cooperation with the requirements of the trial. * Any active autoimmune disease or a documented history of autoimmune disease or syndrome that required systemic treatment in the past 2 years (ie, with use of disease-modifying agents, corticosteroids, or immunosuppressive drugs), except for vitiligo or resolved childhood asthma/atopy NOTE: Other protocol defined Inclusion/Exclusion criteria may apply.

Important: This is the sponsor’s public criteria, not a determination of eligibility. The study team must review your individual situation.

04
Study sites

U.S. locations

  • University of Alabama at Birmingham (UAB)Birmingham, Alabama
  • University of California San Diego (UCSD)La Jolla, California
  • Memorial Cancer Institute at Memorial Regional HospitalHollywood, Florida
  • Hematology Oncology Associates Of The Treasure CoastPort Saint Lucie, Florida
  • Florida Cancer Specialists (Administration and Drug Shipment)The Villages, Florida
  • Northwestern Memorial HospitalChicago, Illinois
  • Ochsner Clinic FoundationJefferson, Louisiana
  • Henry Ford HospitalDetroit, Michigan
  • Virginia Cancer Specialists, PCFairfax, Virginia
  • Medical Oncology Associated, PS (dba Summit Cancer Centers)Spokane, Washington
  • The Border Cancer HospitalAlbury, New South Wales
  • Pindara Private HospitalBenowa, Queensland

Source and freshness
Processed from ClinicalTrials.gov. Last public update: Jun 1, 2026. Always confirm current availability with the study team.

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