Study With Various Immunotherapy Treatments in Participants With Lung Cancer
The purpose of this study is to assess the objective response rate (ORR) of immunotherapy-based combination therapy and to assess the safety and tolerability of immunotherapy-based combination therapy.
Checked against the public recordLast updated Jun 1, 2026 · Source: ClinicalTrials.gov
What this study is about
- Purpose
- Treatment
- Study type
- Interventional
- Phase
- Phase 2
- Sponsor
- Gilead Sciences
- Interventions being studied
- Drug: Domvanalimab; Drug: Quemliclustat; Drug: Zimberelimab; Drug: Docetaxel; Drug: Platinum-Based Doublet
How this study is categorized
These labels come from structured fields and exact terms in the public record.
Who may be able to participate
Inclusion Criteria: * Histologically or cytologically documented Stage IV metastatic, NSCLC * Eastern Cooperative Oncology Group performance status (ECOG PS) of 0 to 1 * At least one measurable target lesion per RECIST v1.1. * Adequate organ function * Participants must be willing to provide adequate tumor tissue Exclusion Criteria: * Underlying medical conditions that, in the Investigator's or Sponsor's opinion, will make the administration of Investigational Product(s) (IPs) hazardous * Use of any live vaccines against infectious diseases within 28 days of first dose of IP(s). * Use of supra-physiologic doses of corticosteroids (\> 10 mg/day of oral prednisone or equivalent) or immunosuppressive medications ≤ 14 days before the initiation of study treatment (absorbable topical corticosteroids are not excluded). * Has known psychiatric or substance abuse disorders that would interfere with cooperation with the requirements of the trial. * Any active autoimmune disease or a documented history of autoimmune disease or syndrome that required systemic treatment in the past 2 years (ie, with use of disease-modifying agents, corticosteroids, or immunosuppressive drugs), except for vitiligo or resolved childhood asthma/atopy NOTE: Other protocol defined Inclusion/Exclusion criteria may apply.
Important: This is the sponsor’s public criteria, not a determination of eligibility. The study team must review your individual situation.
U.S. locations
- University of Alabama at Birmingham (UAB)Birmingham, Alabama
- University of California San Diego (UCSD)La Jolla, California
- Memorial Cancer Institute at Memorial Regional HospitalHollywood, Florida
- Hematology Oncology Associates Of The Treasure CoastPort Saint Lucie, Florida
- Florida Cancer Specialists (Administration and Drug Shipment)The Villages, Florida
- Northwestern Memorial HospitalChicago, Illinois
- Ochsner Clinic FoundationJefferson, Louisiana
- Henry Ford HospitalDetroit, Michigan
- Virginia Cancer Specialists, PCFairfax, Virginia
- Medical Oncology Associated, PS (dba Summit Cancer Centers)Spokane, Washington
- The Border Cancer HospitalAlbury, New South Wales
- Pindara Private HospitalBenowa, Queensland
Source and freshness
Processed from ClinicalTrials.gov. Last public update: Jun 1, 2026. Always confirm current availability with the study team.