The SEQUENCE Trial

Study summary

This study will randomize participants undergoing a bronchoscopic biopsy of a peripheral pulmonary nodule for their standard of care to receive robotic-assisted bronchoscopy (RaB) and then staging linear endobronchial ultrasounnd (EBUS) OR staging linear EBUS first, followed by RaB. The goal of this study is to set the standard for optimizing the sequence of bronchoscopic procedures in patients at risk for early-stage malignancy.

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Key things to know

Main goalDiagnostic

This describes the study’s primary purpose.

What is being studiedLinear EBUS first and Robotic-assisted bronchoscopy first

The study team can explain what participation involves.

Who it may be forEarly-stage or resectable

These are broad labels—not an eligibility decision.

Checked against the public recordLast updated Aug 25, 2026 · Source: ClinicalTrials.gov

Is enrollment open?Recruiting

The study is currently accepting participants.

What kind of study?Not applicable

Interventional

Where is it offered?5 U.S. locations

Locations may change over time.

Who runs it?Northwestern University

Study sponsor

Study overview

What this study is about

Purpose: Diagnostic
Study type: Interventional
Phase: Not applicable
Sponsor: Northwestern University
Interventions being studied: Diagnostic Test: Linear EBUS first; Diagnostic Test: Robotic-assisted bronchoscopy first

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How this study is categorized

These labels come from structured fields and exact terms in the public record.

Disease setting

Early-stage or resectable→

Public criteria

Who may be able to participate

The sponsor separates these requirements into two groups. You do not need to interpret them alone—use them to guide a conversation with the study team.

Requirements people may need to meetInclusion criteria

Peripheral Pulmonary Nodule undergoing a robotic-assisted bronchoscopy

Reasons someone may not be able to joinExclusion criteria

lymph nodes that are enlarged or PET avid on CT prior to procedure

Important: This is the sponsor’s public criteria, not a determination of eligibility. The study team must review your individual situation.

Study sites

U.S. locations

University of California, DavisSacramento, California
Northwestern UniversityChicago, Illinois
Johns Hopkins UniversityBaltimore, Maryland
University of MichiganAnn Arbor, Michigan
University of North Carolina, Chapel HillChapel Hill, North Carolina

Source and freshness
Processed from ClinicalTrials.gov. Last public update: Aug 25, 2026. Always confirm current availability with the study team.

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