A Study of Lung Cancer Screening in People With Unexplained Weight Loss

Study summary

The researchers are doing this study to see if people with unexplained weight loss who have lung cancer screening are more likely to have or develop lung cancer than people without unexplained weight loss. The lung cancer screening will involve use of low-dose computed tomography (LDCT), a CT scan that gives off very low doses of radiation and can make detailed pictures of the lungs to help find tumors. The study researchers will also analyze participants' blood samples to determine if blood testing can be used to help to diagnose lung cancer.

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Key things to know

Main goalNot specified

This describes the study’s primary purpose.

What is being studiedLow Dose CT imaging and blood draws

Plus 1 other study approaches.

Who it may be forLung Cancer Screening

These are broad labels—not an eligibility decision.

Checked against the public recordLast updated Oct 9, 2026 · Source: ClinicalTrials.gov

Is enrollment open?Recruiting

The study is currently accepting participants.

What kind of study?Not applicable

Observational

Where is it offered?8 U.S. locations

Locations may change over time.

Who runs it?Memorial Sloan Kettering Cancer Center

Study sponsor

Study overview

What this study is about

Purpose: Not specified
Study type: Observational
Phase: Not applicable
Sponsor: Memorial Sloan Kettering Cancer Center
Interventions being studied: Diagnostic Test: Low Dose CT imaging; Other: blood draws; Other: screening questionnaire

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How this study is categorized

These labels come from structured fields and exact terms in the public record.

Public criteria

Who may be able to participate

The sponsor separates these requirements into two groups. You do not need to interpret them alone—use them to guide a conversation with the study team.

Requirements people may need to meetInclusion criteria

Eligible for American Cancer Society lung cancer screening, as follows as per the discretion of the screening team:
Age 50-80 years old
At least 20-pack year history of smoking
Weight loss of 3-10%, defined as UWL, within any timeframe over the past in the 18 months prior to enrollment, that cannot be attributed to an underlying medical condition at the discretion of the enrolling investigator
Note that patients who have 3-10% weight may still be enrolled if the enrolling investigator does not conclude that the weight loss can be attributed to the patient's intentional efforts.
Documented weight loss can be self-reported or extracted from weights obtained during physician visits. However, if self-reported weight loss is contradicted by weight loss documented in the medical record (e.g. a patients states that (s)he lost 10 lbs in the past 6 months, but a weight documented in the medical record does not support that history), the measured and quantified weight change will be used to ascertain eligibility
Life expectancy greater than 1 year, per assessment of the treating clinician.

Reasons someone may not be able to joinExclusion criteria

Currently pregnant or trying to become pregnant via self-report
Prior history of recent CT scan of the chest either through LDCT screening or with a scan of the chest (standard, not LDCT) performed within the past 12 months
Prior history of NSCLC ○ Note that patients with a history of diagnosis of non-lung cancers are eligible for the study.
Currently undergoing or referred for diagnostic evaluation due to clinical suspicion for malignancy (e.g., referred to a medical or surgical oncologist, or scheduled for biopsy on the basis of a suspicious imaging abnormality).
Patients with a germline pathogenic genetic variant who have undergone whole body MRI within the past 12 months
Unable to comply with study procedures

Important: This is the sponsor’s public criteria, not a determination of eligibility. The study team must review your individual situation.

Study sites

U.S. locations

Memorial Sloan Kettering at Basking Ridge (All Protocol Activities)Basking Ridge, New Jersey
Memorial Sloan Kettering Monmouth (All Protocol Activities)Middletown, New Jersey
Memorial Sloan Kettering Bergen (All Protocol Activities)Montvale, New Jersey
Memorial Sloan Kettering Suffolk-Commack (All Protocol Activities)Commack, New York
Memorial Sloan Kettering Westchester (All Protocol Activities)Harrison, New York
Memorial Sloan Kettering Cancer Center (All Protocol Activities)New York, New York
Montefiore Health Systems (Montefiore Medical Center)The Bronx, New York
Memorial Sloan Kettering Nassau (All Protocol Activities)Uniondale, New York

Source and freshness
Processed from ClinicalTrials.gov. Last public update: Oct 9, 2026. Always confirm current availability with the study team.

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