Savolitinib Plus Osimertinib Versus Platinum-based Doublet Chemotherapy in Participants With Non-Small Cell Lung Cancer Who Have Progressed on Osimertinib Treatment

Study summary

Clinical study to investigate the efficacy and safety of savolitinib in combination with osimertinib versus platinum-based doublet chemotherapy in participants with EGFR mutated, MET-overexpressed and/or amplified, locally advanced or metastatic NSCLC who have progressed on treatment with Osimertinib.

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Key things to know

Main goalTreatment

This describes the study’s primary purpose.

What is being studiedSavolitinib and Osimertinib

Plus 3 other study approaches.

Who it may be forNon-small cell lung cancer (NSCLC) · EGFR · MET

These are broad labels—not an eligibility decision.

Checked against the public recordLast updated Aug 6, 2026 · Source: ClinicalTrials.gov

Is enrollment open?Active Not Recruiting

The study is underway but is not accepting new participants.

What kind of study?Phase 3

Interventional

Where is it offered?214 U.S. locations

Locations may change over time.

Who runs it?AstraZeneca

Study sponsor

Study overview

What this study is about

Purpose: Treatment
Study type: Interventional
Phase: Phase 3
Sponsor: AstraZeneca
Interventions being studied: Drug: Savolitinib; Drug: Osimertinib; Drug: Pemetrexed; Drug: Cisplatin; Drug: Carboplatin

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How this study is categorized

These labels come from structured fields and exact terms in the public record.

Cancer type

Non-small cell lung cancer (NSCLC)→

Disease setting

Locally advanced→Metastatic or stage IV→

Biomarkers

EGFR→MET→

Treatment approach

Targeted therapy→Chemotherapy→

Public criteria

Who may be able to participate

The sponsor separates these requirements into two groups. You do not need to interpret them alone—use them to guide a conversation with the study team.

Requirements people may need to meetInclusion criteria

Provision of signed and dated written ICF prior to any mandatory and non-mandatory study-specific procedures, sampling and analyses.
Participant must be ≥18 years (≥ 19 years of age in South Korea) at the time of signing the informed consent. All genders are permitted.
Histologically or cytologically confirmed locally advanced or metastatic NSCLC which is not amenable to curative therapy.
Must have at least one documented sensitising EGFR mutation: exon19 deletion, L858R mutation, and/or T790M.
Documented radiologic progression on first- or second-line treatment with osimertinib as the most recent anti-cancer therapy.
Mandatory provision of FFPE tumour tissue.
MET overexpression and/or amplification in tumour specimen collected following progression on prior osimertinib treatment.
Measurable disease as defined by RECIST 1.1.
Adequate haematological, liver, renal and cardiac functions, and coagulation parameters.
ECOG performance status of 0 or 1.

Reasons someone may not be able to joinExclusion criteria

Predominant squamous NSCLC, and small cell lung cancer.
Prior or current treatment with a third-generation EGFR-TKI other than Osimertinib.
Prior or current treatment with savolitinib or another MET inhibitors.
Spinal cord compression or brain metastases, unless asymptomatic and are stable.
History or active leptomeningeal carcinomatosis.
Unresolved toxicities from any prior therapy greater than CTCAE Grade 1 and prior platinum-therapy related Grade 2 neuropathies with the exception of alopecia and haemoglobin ≥ 9.0 g/dL.
Active/unstable cardiac diseases currently or within the last 6 months, clinically significant ECG abnormalities, and/or factors/medications that may affect QTc intervals.
History of liver cirrhosis of any origin and clinical stage; or history of other serious liver disease or chronic disease with relevant liver involvement.
Known serious active infection including, but not limited to, tuberculosis, or HIV, HBV or HCV or gastrointestinal disease.
Receipt of live attenuated vaccine (including against COVID-19) within 30 days prior to the first dose of study intervention.
Past medical history of ILD, drug-induced ILD, radiation pneumonitis, which required steroid treatment, or any evidence of clinically active ILD.
Participants currently receiving medications or herbal supplements known to be strong inducers of cytochrome P450 (CYP)3A4 or strong inhibitors of CYP1A2.

Important: This is the sponsor’s public criteria, not a determination of eligibility. The study team must review your individual situation.

Study sites

U.S. locations

Research SiteOrlando, Florida
Research SiteHonolulu, Hawaii
Research SiteNew Brunswick, New Jersey
Research SiteNew York, New York
Research SiteNashville, Tennessee
Research SiteBuenos Aires
Research SiteCABA
Research SiteFlorida
Research SiteLa Rioja
Research SiteRosario
Research SiteRosario
Research SiteSan Miguel de Tucumán

Source and freshness
Processed from ClinicalTrials.gov. Last public update: Aug 6, 2026. Always confirm current availability with the study team.

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